PAT (Process Analytical Technology) is a valuable timely measurement system of critical parameters that allows the pharmaceutical and chemical industries to enhance the quality and efficiency of chemical process development. RC1e heat flow calorimetry has been embraced as the standard safety and scale up assessment tool. With over thirty years of experience in highly accurate process calorimetry, METTLER TOLEDO developed RTCalTM technology for the RC1e providing highly accurate calorimetry as an inline analytical technique.
RTCalTM technology for the RC1e:
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Reaction calorimetry has been extensively utilized for thermal and kinetic analysis of chemical reactions in the context of thermal process safety and process development. RTCal™ is an innovative technology that is ease-to-use and provides real time heat flow profiles and rapid and accurate measurements under a broad range of reactions conditions. Case studies will be presented exploring the use of RTCal™ as a Process Analytical Technology (PAT) tool.
Case Studies
Your presenter, Dr. Dominique Hebrault, has over ten years experience in process development in the pharmaceutical and chemical industries using automated laboratory tools. He will provide several examples of RTCal™ applications for real-time monitoring of heat flow and online adjustments of reaction conditions in order to reproduce operating conditions of industrial reactors as closely as possible. In addition Dr. Hebrault will demonstrate how RTCal™ was used successfully in the lab environment to ensure that a chemical process and its critical parameters were understood in sufficient detail for a successful and safe scale-up. Specific case studies include:
- In situ measurement of true heat of polymerization reaction with major U changes
- One-click dosing rate optimization for scale-up
- Safe control and real time understanding of hazardous chemistries - Grignard