METTLER TOLEDO
 

Crystallization in the Chemical Industry on-demand webinar

The development of robust crystallization processes in the chemical industry aim to shorten development times where high yields and constant product quality are key. Over the years, there has been a paradigm shift from initially developing the crystallization process as a separated unit operation towards holistic approaches, where the chemical reaction and purification steps upstream, as well as the washing and solid-liquid separation steps downstream, are taken into consideration.

Crystallization in the Chemical Industry - Topics
The first part of this Crystallization in the Chemical Industry webinar will focus on the type of experiments that can be performed at lab scale and how the Lasentec® FBRM® data generated can be used effectively in ensuring a robust process for scale-up through maximizing yield, optimizing the crystal size distribution and minimizing impurities. In the second part of the Crystalllization in the Chemical Industry webinar, the implementation and benefits of Lasentec® FBRM® at pilot and production scale are discussed.


Click to see a preview
Presenter
Your Crystallization in the Chemical Industry presenter, Dr. Jochen Schöll, has extensive experience in the implementation of Process Analytical Technology (PAT) in Crystallization process design and development. Jochen completed his Ph.D. research at ETH Zurich involving the use of Lasentec® FBRM®PVM®, ATR-FTIR and Raman spectroscopy in the characterization of nucleation, growth and polymorph transformation phenomena in the precipitation of organic molecules.

During this Crystallization in the Chemical Industry webinar, Dr.  Schöll provides practical information on the applications of Lasentec® FBRM® and PVM® in crystallization experiments that can be typically found in the chemical industry.

Case studies
A variety of examples of Crystallization in the Chemical Industry will be presented to illustrate the benefits and value of using this technology including:

  • Determination of solubility and metastable zone width and experimental factors impacting the metastable zone
  • Estimation of crystallization kinetics 
  • Designing seeding protocol
  • Optimizing cooling profiles or antisolvent rates to minimize fine crystals and impurities
  • Using the small scale reactor for 'scale down' experiments