The development of robust crystallization processes in the chemical industry aim to shorten development times where high yields and constant product quality are key. Over the years, there has been a paradigm shift from initially developing the crystallization process as a separated unit operation towards holistic approaches, where the chemical reaction and purification steps upstream, as well as the washing and solid-liquid separation steps downstream, are taken into consideration. Crystallization in the Chemical Industry - Topics | ![]() Click to see a preview |
Your Crystallization in the Chemical Industry presenter, Dr. Jochen Schöll, has extensive experience in the implementation of Process Analytical Technology (PAT) in Crystallization process design and development. Jochen completed his Ph.D. research at ETH Zurich involving the use of Lasentec® FBRM®, PVM®, ATR-FTIR and Raman spectroscopy in the characterization of nucleation, growth and polymorph transformation phenomena in the precipitation of organic molecules.
During this Crystallization in the Chemical Industry webinar, Dr. Schöll provides practical information on the applications of Lasentec® FBRM® and PVM® in crystallization experiments that can be typically found in the chemical industry.
Case studies
A variety of examples of Crystallization in the Chemical Industry will be presented to illustrate the benefits and value of using this technology including:
- Determination of solubility and metastable zone width and experimental factors impacting the metastable zone
- Estimation of crystallization kinetics
- Designing seeding protocol
- Optimizing cooling profiles or antisolvent rates to minimize fine crystals and impurities
- Using the small scale reactor for 'scale down' experiments
Improving crystallization and precipitation: a review of 20 years of crystallization best practice
Rapid crystallization development and scale-up using Lasentec® tools
Maximizing the value of crystallization experiments with Lasentec® FBRM®
Tools for Crystallization Scale-Up
Crystallization: from screening to optimization using smart lab reactors (English) (en Francais)
Maximizing the value of crystallization through supersaturation measurement using ReactIRTM

