Supersaturation Monitoring and Control during Crystallization Using In Situ Mid Infrared Spectroscopy: Part 1

Supersaturation is the driving force for all crystallizations from solution. Supersaturation is the fundamental parameter that impacts the outcome of crystallization processes, such as chemical purity, polymorphic content, crystal dimension and shape, and batch to batch consistency of the product.  A science based design and control of a solution crystallization process requires quantification of supersaturation throughout the crystallization process. Without proper in situ analytical techniques, however, measurement of supersaturation during the crystallization is very challenging. The unique capability of ReactIR™, a probe-based FTIR with multivariate quantification, for in situ measurement of solution concentration in a solid-liquid phase, enables real-time monitoring of supersaturation during solution crystallization.

Supersaturation Webinar Details – Part 1
This Supersaturation webinar series provides the knowledge to help tackle critical problems in your crystallization processes using this enabling technique.  Part 1 of this webinar will focus on supersaturation monitoring during crystallization. Part 2, scheduled for later in 2009, will address supersaturation control employing Automated Lab Reactors.