The failure to recognize a non-scalable reaction during early development can lead to potential batch failures, purity and yield inconsistencies, re-development of processes and even delays in delivering compounds. |  Preview the Non-Scalable Reactions On-Demand Webinar |
In addition, there will be discussion on how to define safer and more efficient reaction conditions, including:
- Dosing rate
- Reaction temperature
- Stirring rate
- Reaction time
Applications examples presented during the on-demand webinar include:
- Bromination of disubstituted aniline (Johnson & Johnson)
- Transmetallation and deprotection reactions
- Acetylation in pseudo-adiabatic mode
- Urea cyclization
- Chlorination of dibenzyl phosphite
- Grignard reaction
Your online presenter, Simon Rea, has extensive experience with process development and optimization of chemical reactions.
Related topics: non-scalable reaction, reaction conditions, batch failures, lab scale, heat flow data, pharmaceutical industry, dosing rate, reaction temperature, stirring rate, reaction time, process development, chemical reaction optimization, Bromination of disubstituted aniline, Transmetallation and deprotection reactions, Acetylation in pseudo-adiabatic mode, Urea cyclization, Chlorination of dibenzyl phosphite, Grignard reaction