| The Ugi reaction involves the mixing of four components: an aldehyde, an amine, a carboxylic acid and an isonitrile. The Ugi reaction is a convenient reaction to generate diverse libraries and has been used in the past to generate antimalarial compounds. The particular Ugi reaction that we will consider involves the reaction of furfurylamine, benzaldehyde, boc-glycine and t-butylisonitrile. This reaction produces a Ugi product as a precipitate when run at 0.5M concentration in methanol. We will describe the optimization of this reaction by varying the solvent, concentration and excess of some of the reagents. |  Click to preview the webinar |
Parallel Synthesis
Parallel synthesis is a technique used by scientists to answer important research questions. Parallel synthesis saves time and maximizes data collected from precious starting materials. MiniBlock®is a flexible, easy to use tool designed for parallel synthesis. MiniBlock®is the only compact parallel synthesizer that allows synthesis via solid or solution phase, as well as purification to be carried out on the same platform.
Parallel synthesis is a technique used by scientists to answer important research questions. Parallel synthesis saves time and maximizes data collected from precious starting materials. MiniBlock®is a flexible, easy to use tool designed for parallel synthesis. MiniBlock®is the only compact parallel synthesizer that allows synthesis via solid or solution phase, as well as purification to be carried out on the same platform.
Today, more chemists choose MiniBlock®to increase their productivity than any other similar tool. Originally designed by medicinal and combinatorial chemists at Bristol-Myers Squibb Company, the MiniBlock®has been further developed to address a wide range of chemistry methodologies. Maximize productivity and improve throughput with MiniBlock®.
