A scalable and cost efficient synthetic route to diformylarylbenzene was investigated. It involved a double formylation step that relies on the use of 2-nitropropane as a primary reagent. Due to the inherent energetic nature of nitroalkanes, a process safety assessment was necessary. This Safe Scale-up webinar will demonstrate how process information gained from three RC1e experiments using iC Safety™ - a module for data evaluation available in iControl RC1e™ software - showed the experimental conditions required to match reaction exotherm with plant cooling capacity. In addition the various thermodynamic and worst case scenario trends available in iC Safety™ allowed Weylchem to define safer and more efficient reaction conditions including dosing time, start temperature, digest temperature, and reaction time. |  Preview the Safe Scale-up On-Demand Webinar |
Guest Webinar Presenter: Kevin Drost, WeylChem
Your online presenter is Kevin Drost. Kevin is a Senior Process Chemist at WeylChem.
Your online presenter is Kevin Drost. Kevin is a Senior Process Chemist at WeylChem.
Interested in this webinar? Then you may also be interested in our Free Process Safety and Thermal Hazard Analysis On-Demand Webinar Series:
| On-Demand Webinar Title | Date Presented | Presenter |
| 20 Years of Reaction Calorimetry at Johnson and Johnson | Feb 11, 2009 | Stephen M. Stefanick - Johnson and Johnson |
| A Faster Route to Safe Process Design: iC Safety | Dec 3, 2008 | Leen Schellekens |
| Reducing Risk of Highly Reactive Chemistry in Chemical R&D, Part II | Nov 19, 2008 | Paul Scholl |
| Avoiding Incidents at Scale-up | Nov 12, 2008 | Francis Stoessel - Swiss Safety Institute |
| Calorimetry Best Practice: From LaPlace and Lavoisier to RTCal | Oct 8, 2008 | Steve Czapko |
| RTCal: New Applications for Real Time Calorimetry | Nov 29, 2007 | Simon Rea |