Dissolution and disintegration testing are well established as standard analytical tests used during pharmaceutical development. Yet, if dissolution is inconsistent, what is the root cause? Was the internal tablet or capsule structure inconsistent? Were the particle disintegration and erosion mechanisms inconsistent? Was there an upstream processing inconsistency that resulted in poor tablet properties? With the advent of in-process real-time particle characterization tools, such as FBRM®, it is now possible to use Process Analytical Technology (PAT) tools within the dissolution apparatus to track the particle disintegration, erosion, and dissolution quickly and effectively. Experiments can easily be performed to map the design space relating real time particle distributions to tablet properties, raw materials, and upstream formulation processing. The root cause of dissolution can often be uncovered by linking in situ particle behavior to change in raw materials, over/under granulation, segregation, or changes in compression force. |  Preview the Dissolution On-Demand Webinar |
During the Dissolution webinar, recent case studies will be presented showing how FBRM® and other PAT in situ tools have been used in dissolution tests to gain valuable formulation and process understanding.
If you are interested in this webinar, then you may also be interested in our Process Analytical Technology (PAT) - Formulations and Drug Product On-Demand Webinars:
If you are interested in this webinar, then you may also be interested in our Process Analytical Technology (PAT) - Formulations and Drug Product On-Demand Webinars:
| Optimization of High Shear Wet Granulation Scale-up Using FBRM® and PVM | Dec 2, 2008 | Ben Smith |
| Understanding Disintegration and Dissolution for Improved Solid Formulations Development | Nov 5, 2008 | Ian Haley |
| Optimization of High Shear Wet Granulation using FBRM and PVM | Oct 7, 2008 | Ben Smith |
| Process Analytical Technology (PAT) Monitoring of Solid Dosage Formulations - Part II | Apr 30, 2008 | Ian Haley |
| Particle characterization in granulation and milling | Sep 12, 2007 | Ian Haley |
| PAT: online Partikelgrössenmessung in festen galenischen Formen | Mar 22, 2007 | Jochen Schoell |
| PAT Monitoring of Solid Dosage Formulations | Feb 22, 2007 | Ben Smith |