CH functionalisering is een snel groeiend gebied van onderzoek in de afgelopen 20 jaar. In deze context is het belangrijk om het effect van de katalysator, substraat en carbenoid precursors te begrijpen op de snelheid en efficiëntie van rhodium gekatalyseerde reacties. Een van de technieken beschikbaar om hun invloed te bestuderen is ReactIR ™ in situ spectroscopie.
Of the many challenges facing researchers when investigating and developing these chemical reactions, it is important to understand the impact of the catalyst, substrate and precursor on the reaction rate and mechanism. There are many techniques available to researchers that offer answers to these key questions. One of those techniques is ReactIR™ in situ spectroscopy.ReactIR™ is a real-time in situ reaction analysis system used by researchers to increase their understanding of organic chemistry. ReactIR™ monitors reactive chemistry using well understood mid-IR spectroscopy. A robust ATR probe is inserted directly into the vessel, providing a ‘molecular video’ of the reaction. The concentration changes of all key reactive and transient specimens are monitored allowing for mechanism and pathway determination. Accurate kinetic analysis is achieved with an automated comprehensive data set collection analyzed using iC Kinetics™ software. This generates a kinetic model in fewer experiments than the traditional approach.
Professor Huw M. L. Davies of Emory University is one of the world’s leading researchers in the area of catalytic asymmetric C-H functinalization. His research interests include the design and development of chiral catalysts, new synthetic methodology and the total synthesis of biologically active natural products. Professor Davies‘ group use ReactIR™ in situ spectroscopy and iC Kinetics™ as complementary technologies in order to offer key insights into the mechanism and kinetics of the reactions under investigation. In the Impact of FTIR Studies on the Understanding of Asymmetric Rhodium Catalyzed Carbenoid Reactions webinar, Professor Davies delivers his great insight into the work of his group and demonstrates how these technologies were used in a research context.