The parallel synthesis of γ-turn-inspired peptidomimetic libraries in a MiniBlock XT

Fenster, E.; Rayabarapu, D.; Zhang, M.; Mukherjee, S.; Hill, D.; Neuenswander, B.; Schoenen, F.; Hanson, P.; Aubé, P. Three-Component Synthesis of 1,4-Diazepin-5-ones and the Construction of γ-Turn-like Peptidomimetic Libraries. J. Comb. Chem. 2007, xxx, 000-000.

The parallel synthesis of γ-turn-inspired peptidomimetic libraries has been demonstrated through two approaches toward the preparation of 1,4-diazepin-5-ones. In the first approach, 1,4-diazepin-5-ones scaffolds were prepared on gram scale and subsequently diversified to produce libraries. In a second approach, libraries of 1,4-diazepin-5-ones were produced directly through a three-component strategy that maximizes the diversity obtained in a single step.

Three-Component Synthesis of 1,4-Diazepin-5-ones and the Construction of γ-Turn-like Peptidomimetic Libraries

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• MiniBlock XT

Applications

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• The parallel synthesis of γ-turn-inspired peptidomimetic libraries in a MiniBlock XT