Olefin Synthesis - Sub-Ambient Termperatures and Inert Atmosphere

Horner-Wadsworth-Emmons Olefination Reaction

The Horner–Wadsworth-Emmons reaction is a variant of the Wittig reaction, used in the synthesis of compounds containing carbon-carbon double bonds. The synthesis below demonstrates the reaction between the carbanion of trimethylphosphonoacetate with carbonyl compounds such as phenylacetaldehyde in the MiniBlock XT.

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Products and Solutions

• MiniBlock XT

Applications

• Organometallic Reaction (pdf - 113 KB)
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