Using ReactIR in Chemical Development - GlaxoSmithKline

In one example, NBS coupling of propargyl alcohol with dihydrofuran was being scaled to 50 L for a campaign to make toxicology material. Because ReactIR^TM data showed the reaction to be complete during the first 90 minutes, the project team was able to implement a three-hour, rather than overnight, reaction. This allowed them to run two batches per week and shave two and a half weeks off of a campaign that was originally scheduled to run for five.

In beta tests with the ReactIR™ iC10, users with no prior ReactIR^TM experience were asked to test the instrument. In the deprotonation of an amine to be used in a downstream alkylation, the chemist needed to know how long to stir the deprotonation with sodium carbonate before alkylating.  Data from the ReactIR™ iC10 showed that the reaction was complete within a couple of hours – something that could not be seen by offline analysis.

In another example, a chemist wanted to know how long it took for complete formation of an imine. ReactIR™ iC10 data clearly showed the ketone (carbonyl peak at 1730cm-1) was partially consumed during the course of the reaction and that the reaction never went to completion under those conditions.

ReactIR^TM has proven to be a great tool for freeing up resources and shortening cycle times at GlaxoSmithKline (GSK). It is particularly helpful in reaction monitoring where there are no chromophores. The user-friendliness of the ReactIR™ iC10 should prove beneficial in a number of applications