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Mechanical Properties of Granules Produced by a Wet Granulation Process - Amgen
Michael Cheng, Homer Lin
Amgen Inc.
Amgen Inc.
A Lasentec® D600L with FBRM® technology proved successful in measuring particle size distribution during tablet disintegration. FBRM® data showed that high-water-level granules were more sensitive to compression time than low-water-level granules, indicating that they are impacted more by dwell time in the granulator.
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Products and Solutions
Applications
- At-Line Wet Granule Growth Measurements via FBRM® for Granulation Endpoint Determination and Control
- To Understand the Particle Growth Behavior During Hot Melt Granulation Using FBRM®
- Monitoring In-Process Particle Behavior During High-Shear Granulation with Lasentec® FBRM®
- Use of Lasentec FBRM In-Process Particle Sizing Bottom Spray Fluid Bed Granulation Process (pdf - 1 MB)