Combinatorial Synthesis of Substituted Biaryls and Heterocyclic Arylamines

Ma, Y.; Margarida, L.; Brookes, J; Makara, G.; Berk, S. Combinatorial Synthesis of Substituted Biaryls and Heterocyclic Arylamines. J. Comb. Chem. 2004, 6, 426-430.

In this paper, we report very general conditions that enable palladium-mediated coupling reactions on the solid support. A wide variety of biaryls and arylamines (including pyrimidines) have been synthesized using this protocol. The chemistry facilitates a combinatorial approach to the production of large numbers of medicinally relevant heterocyclic structures.

Combinatorial Synthesis of Substituted Biaryls and Heterocyclic Arylamines

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