FBRM® S400C Technology

FBRM® [Focused Beam Reflectance Measurement] is a real-time quantitative measurement tracking the rate and degree of change to particles, particle structures, and droplets as they actually exist in process. The inline FBRM® measurement enables engineers to quickly link particle system dynamics to processing conditions.

Measure particles and droplets in real time

• Understand Your Particle System – FBRM® provides chemists and engineers with real-time continuous measurement of the particle or droplet system, tracking changes in dimension, shape, and population.
• Identify Critical Process Parameters – FBRM® provides immediate insight into the particle system enabling chemists and chemical engineers to quickly screen experimental parameters and develop a scalable process in early process development.
• Control Batch-to-Batch Repeatability – FBRM® trends enable you to identify and troubleshoot unexpected and undesirable process variations. FBRM® is used to minimize batch failures, improve yield, and troubleshoot scale-up or technology transfer.
• Ensure product quality – By understanding the particle performance, chemists and engineers can link upstream process control parameters (addition rate, mixing rate, or temperature) to downstream process efficiency (filtration/separations efficiency, dissolution rate, etc.) and optimize product quality (yield, bulk density).

After purchasing Lasentec® in 2001, METTLER TOLEDO has become the world leader for inline particle/droplet size, shape, and count characterization.