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Best Practices for QbD Experiments

Quality by Design (QbD) consists of rapidly changing process and product development methods used throughout the pharmaceutical industry. QbD studies require the highest quality of experimental equipment and Process Analytical Technology (PAT) to ensure an accurate determination of process variability and maximum confidence in the proposed design space.
Verminder de risico's van het opschalen van explosieve compounds

Challenges exist during the development and scale-up of highly energetic materials. In addition to achieving the desired yield, purity, and particle size distribution, process safety issues associated with explosive compounds must also be addressed. Risks can be reduced or eliminated by using reaction calorimetry and in situ FTIR reaction monitoring.
Investigate Chemical Processes Safely

METTLER TOLEDO has over 30 years of experience in calorimetry and building instrumentation for safety investigations. The Reaction Calorimeter RC1 is the industry’s “Gold Standard” for measuring heat profiles, enthalpies, chemical conversion, and heat transfer of the desired process under process-like conditions. Together with the software iC Safety™ scientists and engineers are given the critical safety information to design safe processes in a safe manner.
Applications of the RC1e Calorimeter for Process Safety and Scale-Up

Allen M. Beard (Albemarle, USA) reported on the reaction modeling and process development of a fine chemical compound (4-Fluorobenzaldehyde). Kinetic data (ReactIR) and heat of reaction data (RC1e calorimetry) are key components of a safe and efficient scale-up to production.
AutoChem Customer Community Site Version 2 Launched

Reduce the risks of highly reactive chemistry

Chemists design synthesis steps involving highly reactive, unstable and toxic reagents or intermediates day by day. Optimization of highly reactive chemistry requires creativity to maximize yield. The process has to be safe and scalable. AutoChem reactors and process analytical technology help researchers quickly characterize and optimize their most difficult chemistry.
New lab reactor software provides efficient control and data evaluation

Characterize your Reaction at a Glance with Real-Time Heat Flux Information

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