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Datum | Alfabetisch
| Onderzoek de veiligheid in chemische processen Understanding a chemical process in detail significantly reduces the risk of failures at large scale. With RTCal™ real time calorimetry the heat release of a process is measured in real time allowing the ideal dosing profile to be set. Data collected is converted with iC Safety™ software into relevant safety information to automatically assess the thermal risk of a reaction. |
| Best Practices for QbD Experiments Quality by Design (QbD) consists of rapidly changing process and product development methods used throughout the pharmaceutical industry. QbD studies require the highest quality of experimental equipment and Process Analytical Technology (PAT) to ensure an accurate determination of process variability and maximum confidence in the proposed design space. |
| Verminder de risico's van het opschalen van explosieve compounds Challenges exist during the development and scale-up of highly energetic materials. In addition to achieving the desired yield, purity, and particle size distribution, process safety issues associated with explosive compounds must also be addressed. Risks can be reduced or eliminated by using reaction calorimetry and in situ FTIR reaction monitoring. |
| Investigate Chemical Processes Safely METTLER TOLEDO has over 30 years of experience in calorimetry and building instrumentation for safety investigations. The Reaction Calorimeter RC1 is the industry’s “Gold Standard” for measuring heat profiles, enthalpies, chemical conversion, and heat transfer of the desired process under process-like conditions. Together with the software iC Safety™ scientists and engineers are given the critical safety information to design safe processes in a safe manner. |
| Applications of the RC1e Calorimeter for Process Safety and Scale-Up Allen M. Beard (Albemarle, USA) reported on the reaction modeling and process development of a fine chemical compound (4-Fluorobenzaldehyde). Kinetic data (ReactIR) and heat of reaction data (RC1e calorimetry) are key components of a safe and efficient scale-up to production. |
| Process Analytical Technology (PAT) Tools for Pre-Clinical Pharmaceutical R&D Ben Littler (Vertex Pharmaceuticals, Inc., USA) reported on the use of Process Analytical Technology (PAT) in Pre-Clinical R&D to speed development and reduce time to market. The presented case studies illustrated the use of in situ FTIR reaction monitoring (ReactIR) and heat flow (MultiMax) to meet these objectivies. |
| AutoChem Customer Community Site Version 2 Launched |
| Reduce the risks of highly reactive chemistry Chemists design synthesis steps involving highly reactive, unstable and toxic reagents or intermediates day by day. Optimization of highly reactive chemistry requires creativity to maximize yield. The process has to be safe and scalable. AutoChem reactors and process analytical technology help researchers quickly characterize and optimize their most difficult chemistry. |
| New lab reactor software provides efficient control and data evaluation |
| Characterize your Reaction at a Glance with Real-Time Heat Flux Information |
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