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Datum | Alfabetisch
| New Experimental Techniques for Organic Synthesis The white paper - Chemical Synthesis Beyond the Round Bottom Flask - discusses how newly developed methodologies for chemical syntheses are eliminating key challenges, and introduces the concept of chemical synthesis without the traditional round bottom flask. |
| De makkelijke manier van organische chemie Het OptiMax™synthese werkstation herdefinieert de manier waarop organische chemie wordt uitgevoerd, met eenvoudige, nauwkeurige en reproduceerbare werking. Het elimineert het gebruik van rondbodemkolven, olie- en ijsbaden, verwarmingsmantels en zwaarlijvige cryostaten. Intuïtieve handelingen vereenvoudigen de besturing van de experimenten, welke zonder toezicht kunnen lopen. |
| Best Practices for Crystallization Development White Paper The latest whitepaper – Best Practices for Crystallization Development: A Review of Modern Techniques – demonstrates the methodology used to quickly understand crystal growth, nucleation, size, and shape from within the crystallizer and optimize critical parameters such as the temperature profile, addition rates, and seeding to improve purity, filtration rates, and batch repeatability. |
| Robuuste processen dankzij de vroegtijdige gevarenidentificatie EasyMax™ was designed to meet the challenges of today’s synthetic chemist. Designed as a replacement for the round bottom flask, EasyMax™ is a personal chemistry workstation which eliminates the need to use heating mantles, oil baths, ice baths and cryostats. With no training requirement, EasyMax™ is fast and easy to set up, making users immediately productive. The data logging capabilities of the system capture experimental data which delivers an enhanced understanding of the reaction under investigation, leading to faster reaction optimization and characterization. When used in early stage process development, EasyMax™ delivers key insight to chemists regarding key reaction events. As multiple experiments are completed, EasyMax™ gives the chemist a reproducible ‘chemical rate meter’ in every experiment. |
| Onderzoek de veiligheid in chemische processen Understanding a chemical process in detail significantly reduces the risk of failures at large scale. With RTCal™ real time calorimetry the heat release of a process is measured in real time allowing the ideal dosing profile to be set. Data collected is converted with iC Safety™ software into relevant safety information to automatically assess the thermal risk of a reaction. |
| Best Practices for QbD Experiments Quality by Design (QbD) consists of rapidly changing process and product development methods used throughout the pharmaceutical industry. QbD studies require the highest quality of experimental equipment and Process Analytical Technology (PAT) to ensure an accurate determination of process variability and maximum confidence in the proposed design space. |
| Verminder de risico's van het opschalen van explosieve compounds Challenges exist during the development and scale-up of highly energetic materials. In addition to achieving the desired yield, purity, and particle size distribution, process safety issues associated with explosive compounds must also be addressed. Risks can be reduced or eliminated by using reaction calorimetry and in situ FTIR reaction monitoring. |
| A New Approach to Productivity: Synthesis Made Easy EasyMax™ is a future-oriented personal synthesis workstation, replacing the traditional round-bottom flask. It is simple to use, efficient, safe and requires no cryostat, no PC and only minimal space in the fumehood. EasyMax™ increases productivity in chemical development thanks to higher quality experiments of each single experiment. |
| Investigate Chemical Processes Safely METTLER TOLEDO has over 30 years of experience in calorimetry and building instrumentation for safety investigations. The Reaction Calorimeter RC1 is the industry’s “Gold Standard” for measuring heat profiles, enthalpies, chemical conversion, and heat transfer of the desired process under process-like conditions. Together with the software iC Safety™ scientists and engineers are given the critical safety information to design safe processes in a safe manner. |
| Applications of the RC1e Calorimeter for Process Safety and Scale-Up Allen M. Beard (Albemarle, USA) reported on the reaction modeling and process development of a fine chemical compound (4-Fluorobenzaldehyde). Kinetic data (ReactIR) and heat of reaction data (RC1e calorimetry) are key components of a safe and efficient scale-up to production. |
| Process Analytical Technology (PAT) Tools for Pre-Clinical Pharmaceutical R&D Ben Littler (Vertex Pharmaceuticals, Inc., USA) reported on the use of Process Analytical Technology (PAT) in Pre-Clinical R&D to speed development and reduce time to market. The presented case studies illustrated the use of in situ FTIR reaction monitoring (ReactIR) and heat flow (MultiMax) to meet these objectivies. |
| New Reaction Analysis Data Sheets |
| AutoChem Customer Community Site Version 2 Launched |
| The first automated chemistry development tool that requires no training The new EasyMax™ 102 lab reactor system replaces your round bottom flasks and carries out highly reproducible bench-scale reactions easily. Use the touch-pad with automatic data logging for simpler setup and observation. Oil baths, ice baths, or cryostat belong to the past - EasyMax™ 102 offers you built-in heating and cooling. You spend your time on the science by spending less time on mundane tasks. |
| Reduce the risks of highly reactive chemistry Chemists design synthesis steps involving highly reactive, unstable and toxic reagents or intermediates day by day. Optimization of highly reactive chemistry requires creativity to maximize yield. The process has to be safe and scalable. AutoChem reactors and process analytical technology help researchers quickly characterize and optimize their most difficult chemistry. |
| New lab reactor software provides efficient control and data evaluation |
| Characterize your Reaction at a Glance with Real-Time Heat Flux Information |
| First in Situ Probe-Based Technology to Capture Microscope Quality Images |
| Bestudeer warmteontwikkeling met een druk op de knop |
| Continuous flow chemistry – verbeterd productkwaliteit en opbrengst Continuous flow chemistry is waardevol voor de real time verbetering van productkwaliteit en opbrengst. In situ en in real time reactiemonitoring levert met gebruik van ReactIR™ betrouwbare informatie over de reactievoortgang met specifieke informatie over de reactiestart, de omzetting, het tussenstadium en het eindpunt. ReactIR™ blijkt zeer waardevol, zeker bij het volgen van reacties die lastig te bemonsteren zijn.
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