Materiaal sorteren op::
Datum | Alfabetisch
| Structure-Activity Relationship Study of Prion Inhibition by 2-Aminopyridine-3,5-dicarbonitrile-Based Compounds: Parallel Synthesis, Bioactivity, and in Vitro Pharmacokinetics May, B.; Zorn, J.; Witkop, J.; Sherrill, J.; Wallace, A.; Legname, G.; Prusiner, S.; Cohen, F. Structure-Activity Relationship Study of Prion Inhibition by 2-Aminopyridine-3,5-dicarbonitrile-Based Compounds: Parallel Synthesis, Bioactivity, and in Vitro Pharmacokinetics. J. Med. Chem. 2007, 50, 65-73.
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| Solution Phase Synthesis Using a MiniBlock Pezdirc, L.; Bevk, D.; Grosˇelj, U.; Meden, A; Stanovnik, B.; Svete, J. Combinatorial Solution-Phase Synthesis of Alkyl (1S*,2S*,3R*,5R*,6R*)-1-Alkyl-3-aryl-6-benzoylamino-1-hydroxy-7-oxo-5-phenylhexahydropyrazolo[1,2-a]pyrazole-2-carboxylates J. Comb. Chem. 2007, 9, 717-723.
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| Optimization of the Ugi Reaction Using Parallel Synthesis and Liquid Handling |
| Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain |
| Facile and purification free synthesis of peptides utilizing ROMPgel- and ROMPsphere-supported coupling reagents |
| Cyclic Tetrapeptides via the Ring Contraction Strategy: Chemical Techniques Useful for their Identification |
| A Safety Catch Linker for Fmoc-based Assembly of Constrained Cyclic Peptides |
| Fluorescein-based Amino Acids for Solid Phase Synthesis of Fluorogenic Protease Substrates |
| A Substrate-Phage Approach for Investigating Caspase Specificity |
| A Convenient Method for Synthesis of Cyclic Peptide Libraries |
| Modular Three-Component Solid-Phase Synthesis of Unsymmetrical Guanidines via Resin Capture of Carbodiimides Boguszewski, P.; Rahman, S.; Ganesan, A. Modular Three-Component Solid-Phase Synthesis of Unsymmetrical Guanidines via Resin Capture of Carbodiimides. J. Comb. Chem. 2004, 6, 32-34.
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| Application of Solution-Phase Parallel Synthesis to Preparation of Trisubstituted 1,2,4-Triazoles Martin, S.; Romine, J.; Chen, L.; Mattson, G.; Antal-Zimanyi, I.; Poindexter, G. Application of Solution-Phase Parallel Synthesis to Preparation of Trisubstituted 1,2,4-Triazoles. J. Comb. Chem. 2004, 6, 35-37.
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| Construction of 6-Amino-2,2-Dimethyl-3,4,6-Trisubstituted-2H-1-Benzopyran Library by Solid Phase Synthesis Gong, Y.; Seo, J.; Chon, Y.; Hwang, J.; Park, J.; Yoo, S. Construction of 6-Amino-2,2-Dimethyl-3,4,6-Trisubstituted-2H-1-Benzopyran Library by Solid Phase Synthesis. J. Comb. Chem. 2003, 5, 577-589.
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| Solid-Phase Synthesis of Tetrahydro-1,4-benzodiazepine-2-one Derivatives as a â-Turn Peptidomimetic Library Im, I.; Webb, T.; Gong, Y.; Kim, J.; Kim, Y. Solid-Phase Synthesis of Tetrahydro-1,4-benzodiazepine-2-one Derivatives as a â-Turn Peptidomimetic Library. J. Comb. Chem. 2004, 6, 207-213.
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| Polymer-supported reagents and scavengers to streamline tedious purification steps Yadav-Bhatanagar, N.; Desjonque`res, N.; Mauger, J. Polymer-Supported Approach for Solution-Phase Synthesis of Cysteine Trap Protease Inhibitors: Procedure for Straightforward Optimization of the P1-P1' Pocket. J. Comb. Chem 2002, 4, 49-55.
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| Application of Lean Manufacturing Concepts to Drug Discovery: Rapid Analogue Library Synthesis Weller, H.; Nirschl, D.; Petrillo, E.; Poss, M.; Andres, C.; Cavallaro, C.; Echols, M.; Grant-Young, K.; Houston, J.; Miller, A.; Swann, R. Application of Lean Manufacturing Concepts to Drug Discovery: Rapid Analogue Library Synthesis. J. Comb. Chem. 2006, 8, 664-669.
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| Combinatorial Synthesis of Substituted Biaryls and Heterocyclic Arylamines Ma, Y.; Margarida, L.; Brookes, J; Makara, G.; Berk, S. Combinatorial Synthesis of Substituted Biaryls and Heterocyclic Arylamines. J. Comb. Chem. 2004, 6, 426-430.
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| Emerging Technologies Supporting Chemical Process R&D and Their Increasing Impact on Productivity in the Pharmaceutical Industry Rubin, E.; Tummuala, S.; Both, D.; Wang, C,; Delaney, E. Emerging Technologies Supporting Chemical Process R&D and Their Increasing Impact on Productivity in the Pharmaceutical Industry. <9>Chem. Rev. 2006, 106, 2794-2810.
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| Incorporation of an Intramolecular Hydrogen-Bonding Motif in the Side Chain of 4-Aminoquinolines Enhances Activity against Drug-Resistant P. falciparum Madrid, P.; Liou, A.; DeRisi, J.; Guy, R. Incorporation of an Intramolecular Hydrogen-Bonding Motif in the Side Chain of 4-Aminoquinolines Enhances Activity against Drug-Resistant P. falciparum. J. Med. Chem. 2006, 49, 4535-4543.
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| Uncompetitive Antagonism of AMPA Receptors: Mechanistic Insights from Studies of Polyamine Toxin Derivatives Anderson, T.; Tikhonov, D.; Bølcho, U.; Bolshakov, K.; Nelson, J.; Pluteanu, F.; Mellor, I.; Egebjerg, J.; Strømgaard, K. Uncompetitive Antagonism of AMPA Receptors: Mechanistic Insights from Studies of Polyamine Toxin Derivatives. J. Med. Chem. 2006, 49, 5414-5423.
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| Method for the Solid-Phase Parallel Synthesis of a 6-Alkylamino-2-(functionalized-aminomethyl)-2H-1-benzopyran Library Hwang, J.; Choi, H.; Seo, J.; La, H.; Yoo, S.; Gong, Y. Method for the Solid-Phase Parallel Synthesis of a 6-Alkylamino-2-(functionalized-aminomethyl)-2H-1-benzopyran Library. J. Comb. Chem. 2006, 8, 897-906.
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| Use of Quinolinium Salts in Parallel Synthesis for the Preparation of 4-Amino-2-alkyl-1,2,3,4-tetrahydroquinoline Bazin, M.; Kuhn, C. Use of Quinolinium Salts in Parallel Synthesis for the Preparation of 4-Amino-2-alkyl-1,2,3,4-tetrahydroquinoline. J. Comb. Chem. 2005, 7, 302-308.
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| Solid-phase Synthesis of sn-1,2- and sn-2,3-Diacylglycerols via Ring-Opening of the Glycidyl-Bound Resin Seo, J.; Yoon, C.; Gong, Y. Solid-phase Synthesis of sn-1,2- and sn-2,3-Diacylglycerols via Ring-Opening of the Glycidyl-Bound Resin. J. Comb. Chem. 2007, 9, 366-369.
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| Solid-Phase Synthesis of 5-Amino-1-(Substituted Thiocarbamoyl)pyrazole and 1,2,4-Triazole Derivatives via Dithiocarbazate Linker Hwang, J.; Choi, H., Lee, D.; Yoo, S.; Gong, Y. Solid-Phase Synthesis of 5-Amino-1-(Substituted Thiocarbamoyl)pyrazole and 1,2,4-Triazole Derivatives via Dithiocarbazate Linker. J. Comb. Chem. 2005, 7, 136-141.
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| Parallel Synthesis of 3-Amino-4H-Quinolizin-4-ones, Fused 3-Amino-4H-Pyrimidin-4-ones, and Fused 3-Amino-2H-Pyran-2-ones Cÿ ebasˇek, P.; Bevk, D.; Pirc, S.; Stanovnik, B.; Svete, J. Parallel Synthesis of 3-Amino-4H-Quinolizin-4-ones, Fused 3-Amino-4H-Pyrimidin-4-ones, and Fused 3-Amino-2H-Pyran-2-ones. J. Comb. Chem. 2006, 8, 95-102.
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