Materiaal sorteren op::
Datum | Alfabetisch
| A New Class of Blockers of the Voltage-Gated Potassium Channel Kv1.3 via Modification of the 4- or 7-Position of Khellinone Harvey, A.; Baell, J.; Toovey, N.; Homerick, D.; Wulff, H. A New Class of Blockers of the Voltage-Gated Potassium Channel Kv1.3 via Modification of the 4- or 7-Position of Khellinone. J. Med. Chem. 2006, 49, 1433-1441.
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| Solution-Phase Parallel Synthesis of Hexahydro-1H-isoindolone Libraries via Tactical Combination of Cu-Catalyzed Three-Component Coupling and Diels–Alder Reactions Zhang, L.; Lushington, G.; Neuenswander, B.; Hershberger, J.; Malinakova, H. Solution-Phase Parallel Synthesis of Hexahydro-1H-isoindolone
Libraries via Tactical Combination of Cu-Catalyzed Three-Component Coupling and Diels–Alder Reactions. J. Comb. Chem. 2008, xxx,000-000. |
| Optimization of the Ugi Reaction Using Parallel Synthesis and Liquid Handling |
| Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain |
| Facile and purification free synthesis of peptides utilizing ROMPgel- and ROMPsphere-supported coupling reagents |
| Cyclic Tetrapeptides via the Ring Contraction Strategy: Chemical Techniques Useful for their Identification |
| A Safety Catch Linker for Fmoc-based Assembly of Constrained Cyclic Peptides |
| Fluorescein-based Amino Acids for Solid Phase Synthesis of Fluorogenic Protease Substrates |
| A Substrate-Phage Approach for Investigating Caspase Specificity |
| A Convenient Method for Synthesis of Cyclic Peptide Libraries |
| Application of Solution-Phase Parallel Synthesis to Preparation of Trisubstituted 1,2,4-Triazoles Martin, S.; Romine, J.; Chen, L.; Mattson, G.; Antal-Zimanyi, I.; Poindexter, G. Application of Solution-Phase Parallel Synthesis to Preparation of Trisubstituted 1,2,4-Triazoles. J. Comb. Chem. 2004, 6, 35-37.
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| Solid-Phase Synthesis of Tetrahydro-1,4-benzodiazepine-2-one Derivatives as a â-Turn Peptidomimetic Library Im, I.; Webb, T.; Gong, Y.; Kim, J.; Kim, Y. Solid-Phase Synthesis of Tetrahydro-1,4-benzodiazepine-2-one Derivatives as a â-Turn Peptidomimetic Library. J. Comb. Chem. 2004, 6, 207-213.
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| Organometallic Reaction |
| The parallel synthesis of γ-turn-inspired peptidomimetic libraries in a MiniBlock XT Fenster, E.; Rayabarapu, D.; Zhang, M.; Mukherjee, S.; Hill, D.; Neuenswander, B.; Schoenen, F.; Hanson, P.; Aubé, P. Three-Component Synthesis of 1,4-Diazepin-5-ones and the Construction of γ-Turn-like Peptidomimetic Libraries. J. Comb. Chem. 2007, xxx, 000-000.
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| Application of Lean Manufacturing Concepts to Drug Discovery: Rapid Analogue Library Synthesis Weller, H.; Nirschl, D.; Petrillo, E.; Poss, M.; Andres, C.; Cavallaro, C.; Echols, M.; Grant-Young, K.; Houston, J.; Miller, A.; Swann, R. Application of Lean Manufacturing Concepts to Drug Discovery: Rapid Analogue Library Synthesis. J. Comb. Chem. 2006, 8, 664-669.
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| Novel parallel synthesis of N-(4-oxo-2-substituted-4H-quinazolin-3-yl)-substituted sulfonamides Zhou, Y.; Murphy, D.; Sun, Z.; Gregor, V. Novel parallel synthesis of N-(4-oxo-2-substituted-4H-quinazolin-3-yl)-substituted sulfonamides. Tetrahedron Letters. Published online: September 21, 2004. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6THS-4DCD8HR-P&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=0c461572d3d4942829ca27870347307c (accessed March 1, 2008).
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| Emerging Technologies Supporting Chemical Process R&D and Their Increasing Impact on Productivity in the Pharmaceutical Industry Rubin, E.; Tummuala, S.; Both, D.; Wang, C,; Delaney, E. Emerging Technologies Supporting Chemical Process R&D and Their Increasing Impact on Productivity in the Pharmaceutical Industry. <9>Chem. Rev. 2006, 106, 2794-2810.
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| Parallel Synthesis of 3-Amino-4H-Quinolizin-4-ones, Fused 3-Amino-4H-Pyrimidin-4-ones, and Fused 3-Amino-2H-Pyran-2-ones Cÿ ebasˇek, P.; Bevk, D.; Pirc, S.; Stanovnik, B.; Svete, J. Parallel Synthesis of 3-Amino-4H-Quinolizin-4-ones, Fused 3-Amino-4H-Pyrimidin-4-ones, and Fused 3-Amino-2H-Pyran-2-ones. J. Comb. Chem. 2006, 8, 95-102.
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| One-Step Synthesis of Oxazoline and Dihydrooxazine Libraries Chaudhry, P.; Schoenen, F.; Neuenswander, B.; Lushington, G.; Aube, J. One-Step Synthesis of Oxazoline and Dihydrooxazine Libraries. J. Comb. Chem. 2007, 9, 473-476.
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| Ionic Immobilization, Diversification, and Release: Application to the Generation of a Library of Methionine Aminopeptidase Inhibitors Vedantham, P.; Guerra, J.; Schoenen, F.; Huang, M.; Gor, P.; Georg, G.; Wang, J.; Neuenswander, B.; Lushington, G.; Mitscher, L.; Ye, Q.; Hanson, P. Ionic Immobilization, Diversification, and Release: Application to the Generation of a Library of Methionine Aminopeptidase Inhibitors. J. Comb. Chem. XXXX, xxx, 000–000.
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| Chemical Libraries via Sequential C-H Functionalization of Phenols Li, K.; Tunge, J.; Chemical Libraries via Sequential C-H Functionalization of Phenols. J. Comb. Chem. XXXX, xxx, 000–000.
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| Synthesis of a Polymer-Supported Anthracene and Its Application as a Dienophile Scavenger Lei, X.; Porco, J. Synthesis of a Polymer-Supported
Anthracene and Its Application as a Dienophile Scavenger. Org. Lett. 2004, 6, 795-798. |
| Olefin Synthesis - Sub-Ambient Termperatures and Inert Atmosphere Horner-Wadsworth-Emmons Olefination Reaction
The Horner–Wadsworth-Emmons reaction is a variant of the Wittig reaction, used in the synthesis of compounds containing carbon-carbon double bonds. The synthesis below demonstrates the reaction between the carbanion of trimethylphosphonoacetate with carbonyl compounds such as phenylacetaldehyde in the MiniBlock XT. |
| Grignard Reaction |