METTLER TOLEDO
 

2011 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting

Oct 23, 2011 - Oct 27, 2011
Washington DC USA
2011 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting
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The American Association of Pharmaceutical Scientists is dedicated to being the premier organization of all scientists dedicated to the discovery, development and manufacture of pharmaceutical products and therapies through advances in science and technology.

METTLER TOLEDO made the following presentation at the 2010 AAPS Conference:
 
Below is an extensive list of previous AAPS presentations highlighting how pharmaceutical scientists use METTLER TOLEDO PAT technology to further their research and optimize their manufacturing processes using the principles of Quality by Design (QbD). Some of these papers are also available for download:
  • Non-spectroscopic Inline Particle Size Distribution Determination as the Endpoint for High Shear Wet Granulation – Purdue University (2010)

  • Evaluation of PAT Tools for the Monitoring and Endpoint Detection of the High Shear Wet Granulation: NIR, FBRM®, PVM®, ARS – Novartis (2010)

  • Process Analytical Technology: Online Monitoring of PLGA Microparticles Formation Using FBRM® and PVM® - FDA/CDER/OPS/DPQR (2010)

  • A Mechanistic Study Using Polymers to Sustain Supersaturation upon In-Vitro Dissolution of Liquid Filled Capsule Formulations of a Poorly Soluble Drug Molecule – Amgen (2010)

  • Real-time Particle Size Analysis Using Focused Beam Reflectance Measurement (FBRM®) as a Process Analytical Technology (PAT) – Campbell University and GlaxoSmithKline (2010)

  • Predicting High Shear Wet Milling Behaviors of Pharmaceutical Solids – Pfizer (2010)

  • Quality by Design (QbD) Case Study: Seeking Linkage Between Real-time PAT Process Monitoring and Offline Product Characterization – FDA/CDER/OPS/DPQR (2010)

  • Resolution and Sensitivity of FBRM® C35 Probe for Real-time Chord Length Distribution Measurement During High Shear Wet Granulation and Correlation with Other Particle Size Distribution Techniques – Bristol-Myers Squibb Company (2010)

  • Application of QbD Principles for the Evaluation of Various Hypromellose Grades for a Sustained Release Formulation - GlaxoSmithKline (2010)

  • A Real-time Study of Disintegration and Dissolution in Solid Oral Dosage Forms with Focused Beam Reflectance Measurement (FBRM®) Technology - Abbott Labs PPD R&D (2009)
  • Roller Compaction Process Optimization using FBRM® At-line Particle Characterization Monitoring and Control - Patheon (2009)
  • Formulation Strategies for a Poorly Soluble Drug Molecule Using Liquid Filled Capsules: From Enhancing Solubility to Sustaining Supersaturation - Amgen Inc. (2009)
  • Application of Focused Beam Reflective Measurement (FBRM®) and Process Video Microscopy (PVM®) in Formulation Screening - Novartis Pharmaceuticals (2009)
  • Quality by Design (QbD): A Design of Experiments (DOE) Approach to Examine the Effects of Process Variables on Particle Size Distribution for a Pharmaceutical Co-precipitation Process via a Real-Time Process Monitoring Strategy - Food and Drug Administration (FDA) (2009) 
  • Scale-up and Optimization of a Fluid Bed Coating Process Real-time Particle Monitoring and Control - GEA Niro and Bristol-Myers Squibb (2008)
  • Understanding Dissolution Inconsistency In Situ Disintegration Mechanisms - Distek (2008)
  • Wet Granulation Scale-up and Control with In Situ Particle Characterization - GEA Pharma Systems (2008)
  • High Shear Wet Granulation Processes with In Situ Particle Characterization - GlaxoSmithKline (2008)
  • Determination of Granulation Growth Rates: A Comparison between FBRM® and Sieve Analysis - Purdue University (2007)
  • Use of Focused Beam Reflectance Measurement (FBRM®) To Monitor Drug Dissolution in Microemulsion Preconcentrates - Novartis (2007)
  • Development of a Method for Measuring Particle Size Distribution in Real Time during Disintegration - Amgen, Inc. (2007)
  • In-vitro Selection of Excipients to Enhance the In Vivo Solubility of a Poor Solubility Drug From a Conventional Solid Oral Dosage Form - Merck and Co, Inc. (2007)
  • Investigation of an Atypical Observation of Harder Tablets Having a Faster Dissolution Rate - GlaxoSmithKline (2007)
  • Effect of Chloride Ion and ph on the Dissolution of An Amine Derivative - Wyeth (2007)
  • Mass and Heat Balance in Fluid Bed Spray Granulation - Johnson and Johnson (2006)
  • Effect of Process Variable on Fluid Bed Coating - Inline Monitoring of Pellet Size, Growth and Population - Forest Laboratories, Inc. (2006)
  • Understanding Hydrate Formation During Wet Granulation - Purdue University and University of Copenhagen (2006)

AAPS Annual Meeting 2011 Washington DC