Parallel Solution Phase Synthesis

Synthetic Organic Chemistry

Parallel Organic Synthesis in Solution Phase is widely used by the Synthetic Chemist to answer important research questions. Application areas include drug discovery, process development, polymers and petrochemicals. Chemists can choose from a wide range of existing reactions and employ statistical experimental design to enhance productivity and maximize data collection from precious starting materials.

MIniBlock XT is useful for complex, multi-step synthesis protocols in a variety of reaction conditions. Ideal for reactions run at reflux and under inert conditions, MIniBlock XT uses a flexible reactor. The result - MIniBlock XT handles multiple-step synthesis protocols that require a wide range of reaction scales and arrays.

Informatieaanvraag Vraag een offerte aan

Solution-Phase Parallel Synthesis of Hexahydro-1H-isoindolone Libraries
Parallel solution phase synthesis of a series of libraries involving the synthesis of hexahydro-1H-isoindolones was performed exploiting a novel "tactical combination" of Cu-catalyzed three-component coupling and Diels-Alder reactions. Three distinct libraries consisting of 24, 60, and 32 members were constructed. Additional sub-libraries of isoindolone scaffolds were prepared in a one-pot/two-step process and further diversified via Pd-catalyzed Suzuki cross-coupling reaction with boronic acids.

Source: Zhang, Lushington, Neuenswander, Hershberger, and Malinakova. J. Comb. Chem., 10 (2), 285-302, 2008. University Department of Chemistry, Center for Chemical Methodologies and Library Development.

a-Alkylation of SAMP-Hydrazones
Reactions can be carried out in round bottom or fritted vessels in a variety of sizes. Purification and cleanup are simple: fritted reaction vessels, combined with the unique built-in valve, allow reaction products to be passed through scavenging resins in seconds. The following SAMP reaction required strictly anhydrous conditions at -70 in the presence of corrosive reagents. The reactions were successuflly carried out using MiniBlock fitted with inert atmosphere manifolds. The investigators repeated this reaction sequence in solid phase using a novel SAMP resin, resulting comparable yields.

Source: Prof D. Enders, J. Koebbberling RWTH Aachen, Germany.

Products and Solutions

Applications

Nieuws

Knowhow

Webinars

Seminars en training

Tijdschriften

Archiefmateriaal