Particle Engineering and Wet Milling

Understand, Optimize and Control Crystallization From Laboratory to Manufacturing Plant

Milling of dry powders and other powder processes can cause significant yield losses and can generate dust creating health and safety hazards. Avoiding these processes can improve process safety and can improve process efficiency.

In response to this, there are now many technologies being used or investigated with the goal of producing particles of a specifically designed size distribution. In many cases, with a goal of generating relatively fine crystal product, high levels of supersaturation must be generated. Quite often, FBRM and PVM play a key role in providing real-time measurement and understanding of the particles generated through these intensified processes.

Due to the tendency for many compounds to agglomerate under high supersaturation, it is also common to employ high shear wet milling to break apart agglomerates into primary particles. FBRM is an ideal technology for in situ monitoring of wet milling to detect process endpoint for assurance of consistent product quality.