Predicting and Optimizing Filtration and Drying Cycle Time

Optimizing For Downstream Process Efficiency Involves Avoiding Bottlenecks and Improving Cycle Time

Crystallized product is often separated from the mother liquor by methods of filtration or centrifugation, followed by drying. A wide crystal size distribution with a significant numbers of “fines” often results in poor filterability which can add hours or even days to process cycle time. Poor filterability also relates directly to mother liquor retention which impacts crystal product purity – requiring additional washes with hot solvent which can further increase cycle time and reduce yields.

FBRM process analytical tools are widely used for real-time monitoring and optimization of crystallization for the purpose of avoiding downstream bottlenecks due to poor filterability of the crystal product.