Continuous Crystallization - Monitoring and Control

Real-Time Monitoring of Supersaturation and Crystal Population For Modeling and Control of Continuous Crystallization

Continuous crystallization has long been a standard method for the crystallization of bulk commodity chemicals and large-volume specialty chemicals, but it has only recently become a focus in the pharmaceutical and fine chemical industries.

Advances in process modeling and crystallizer design (including various plug flow crystallizers and mixed-suspension mixed-product removal (MSMPR) crystallizers) take advantage of the capability of real-time control of the crystal size distribution based on direct monitoring of the crystal population using FBRM and real-time monitoring of supersaturation using ReactIR.